Hayes’ research interests are in the field of experimental therapeutics and cancer biomarkers, especially in breast cancer. His work has been particularly focused on development and validation of cancer biomarker tests, such as HER-2, CA15-3, circulating tumor cells and pharmacogenomic markers. He has been instrumental in establishing international guidelines for the use of tumor biomarker tests, including criteria for their clinical utility.
Hayes has served as chair of the SWOG Breast Cancer Translational Medicine Committee, and he was an inaugural member and chaired the American Society of Clinical Oncology (ASCO) Tumor Marker Guidelines Committee. He has been instrumental in the joint ad hoc committees between ASCO and the College of American Pathologists.
Hayes also served on the ASCO board of directors as well a three-year term as president of ASCO from 2016-2018. He is a fellow of ASCO, a fellow of the American College of Physicians, a past Komen Scholar, an emeritus of the Breast Cancer Research Foundation, and a member of the Association of American Physicians and of the American Clinical and Climatologic Association. He has been the recipient of the ASCO Gianni Bonadonna Award in breast cancer (2007), the ASCO Allen Lichter Visionary Leadership Award (2021), and the Susan G. Komen Brinker Award for Scientific Distinction in Clinical Research (2023). He received the Distinguished Alumni Award from the Indiana University Medical School (2024).
He lives in Ann Arbor, Mich., with his wife, Jane. They have two sons and four granddaughters.